Recently, I faced this error in our Docker-Container environment. All the necessary packages were already installed but still, I was facing this clueless error. I search a bit and after an hour and so I found the exact reason and solution for this error. To know more about this error in detail. Please follow this Github thread. https://github.com/mkleehammer/pyodbc/issues/610 https://github.com/mkleehammer/pyodbc/issues/610#issuecomment-587523802 Solution: It's because the server's certificate has too weak a key. In case you are using Linux env directly/not the Docker one. Just edited /etc/ssl/openssl.cnf and change these 2 lines. MinProtocol = TLSv1.0 CipherString = DEFAULT@SECLEVEL=1 In case you are also using a container, please add these three lines to your Docker file. RUN chmod +rwx /etc/ssl/openssl.cnf RUN sed -i ' s/TLSv1.2/TLSv1/g ' /etc/ssl/openssl.cnf RUN sed -i ' s/SECLEVEL=2/SECLEVEL=1/g ' /etc/ssl/openssl.cnf Thanks!! Enjoy Programming! Refer...